This Technology Platform deals with miniaturized solutions for the detection of diseases by analysis of both gases and fluids. Traces of specific gases in breath are an early marker for a number of diseases including cancer. Analysis by miniaturized chemical sensing systems with a MEMS based ion mobility spectrometer as core component will lead to fast screening methods. Optical sensors for mobile Point-of-Care diagnostics make use of integrated optical devices like micro ring resonators with functionalized surfaces. Docking of specific antibodies on those surfaces will change the optical properties of the devices which can be used for detection with high sensitivity and high throughput. Besides development of components and systems, the design of the surfaces itself as well as surface characterization for optimization of analysis are part of the work.